Welcome to the Lewis laboratory website! We study how chromatin dynamics influences gene expression during mammalian development and tumorigenesis.


Our research program is rooted in the idea that chromatin, the physiologically relevant form of eukaryotic genomes, contains an indexing system that represents a fundamental regulatory mechanism that operates outside of the DNA sequence itself.

Covalent modifications to DNA and histones - the proteins that package our genome - are implicated in the regulation of gene expression and the stable maintenance of cell type-specific gene expression patterns and cellular identity.


Recent genome-wide sequencing studies have discovered numerous somatic mutations in chromatin modifying factors in many types of human cancers. The collective number of oncogenic mutations has led to the emerging view of “driver mutations” in chromatin regulators underlying many human cancers.


A long-term goal of our research program is elucidating the contribution of inheritable chromatin states in the maintenance of gene expression programs involved in normal and neoplastic development.

The Lewis Lab, Wisconsin Institute for Discovery, Madison, WI 53715

©2017 Board of Regents of the University of Wisconsin System

Openings available (October 2017):


Postdoctoral positions

Join the Lewis Lab as a postdoc! We’re looking for highly motivated candidates with a strong background in biochemistry, genetics, molecular biology, or bioinformatics. 

Lewis Laboratory


@Wisconsin Institute for Discovery