Welcome to the Lewis lab website! We study how chromatin dynamics influences gene expression during mammalian development and tumorigenesis.


Our research program is rooted in the idea that chromatin, the physiologically relevant form of eukaryotic genomes, contains an indexing system that represents a fundamental regulatory mechanism that operates outside of the DNA sequence itself. Covalent modifications to DNA and histones - the proteins that package our genome - are implicated in the regulation of gene expression and the stable maintenance of cell type-specific gene expression patterns and cellular identity. Recently, genome-wide sequencing technologies have allowed the notable discovery of somatic mutations in chromatin modifying factors in many types of human cancers. The collective number of oncogenic mutations has led to the emerging view of “driver mutations” in chromatin regulators underlying many human cancers.



A long-term goal of our research program is elucidating the contribution of chromatin structure to the establishment and maintenance of gene expression programs involved in normal and neoplastic development.

 




The Lewis Lab, Wisconsin Institute for Discovery, Madison, WI 53715

©2015 Board of Regents of the University of Wisconsin System

Openings available (August 2017):


Postdoctoral associate/fellow positions

Join the Lewis Lab as a postdoc! We’re looking for highly motivated candidates with a strong background in biochemistry, genetics, molecular biology, or bioinformatics.